Basic Information
Name of the priority area of scientific development for which the application is submitted: Sustainable development of the agro-industrial complex
Name of the specialized scientific research area: Intensive animal husbandry
Scientific director of the project/program: G.S.Bekova, PhD
Implementation period, its duration in months: 01.02.2025 – 31.12.2027, duration – 35 months.
Total funding volume and by year: 30 000 000 tenge
2025 year – 10 000 000 tenge
2026 year – 10 000 000 tenge
2027 year – 10 000 000 tenge
Object of research, development or design: Kushum horse breed
Objective of the project/program: to establish SNPs associated with growth and development rates in Kushum horses based on SNP genotyping data, characterize their biological role and quantify their phenotypic effects to improve the method of animal selection and use in marker selection.
- To study the genetic diversity of the Kushum horse breed populations by genotyping with broad genome coverage.
- To identify SNP polymorphisms associated with growth and development rates in Kushum horses.
- To characterize the genomic localization of the identified SNPs of high significance of association with the studied traits in Kushum horses
- To determine the genes containing SNPs associated with the productive qualities of Kushum horses.
- To characterize the biological role of genes containing SNPs and to analyze possible gene networks involved in the regulation and phenotypic implementation of the productive qualities of horses
- To provide a quantitative assessment of the phenotypic effects of SNPs marking an increased level of animal productivity.
- To develop a recommendation with a list of marker SNPs affecting the productive qualities of Kushum horses.
The prerequisite for the development of the project is the dissertation research of G.S.Bekova on the topic: "Study of genomes associated with the productivity of horses bred in Kazakhstan", carried out on the basis of the Institute of Veterinary Medicine and Agrotechnology of the West Kazakhstan Agrarian and Technical University named after Zhangir Khan" within the framework of the educational program 8D080200-Technology of livestock production 2022-2024.
The results of the study of genomic and gene localization of high-significance SNP association with meat traits in Kushum horses planned to be obtained within the framework of the project will allow in the future to conduct a comparative analysis with the genomic data of Jabe horses and determine the commonality or breed specificity of the genome regions responsible for controlling the rates of growth and development. This will allow obtaining not only comparative, but also prognostic data regarding other breeds and adjusting the scope of the search when conducting similar studies in the future. Theoretically, marker SNPs localized in genome regions saturated with SNP markers of other breeds should be characterized by breed-resistant phenotypic effects, which will also bring us closer to the development of a breed-universal DNA panel for early diagnostics of horse growth and development rates.
The results of the project can be used to provide services for genetic assessment of productivity potential to private and state farms, which will significantly increase the competitiveness of the developer organization in the market of similar and analogous genetic services.
As a result of the project implementation:
- the genetic diversity of the Kushum horse breed will be studied by genotyping with broad genome coverage;
- SNP polymorphisms associated with growth and development rates in Kushum horses will be identified;
- the genomic localization of the identified SNPs of high significance association with the studied traits in Kushum horses will be characterized;
- genes containing SNPs associated with the productive qualities of Kushum horses will be identified;
- the biological role of genes containing SNPs will be characterized and possible gene networks involved in the regulation and phenotypic implementation of the productive qualities of horses will be analyzed;
- a quantitative assessment of the phenotypic effects of SNPs marking an increased level of animal productivity will be given;
- a recommendation with a list of marker SNPs affecting the productive qualities of Kushum horses will be developed.
Degree of implementation: no
Article in a journal from the first three quartiles of the impact factor in the Web of Science database or having a CiteScore percentile in the Scopus database of at least 50.